Gene: MAP4K5

  • Entrez Gene ID

  • Symbol

    • MAP4K5
  • Synonyms

    • GCKR, KHS, KHS1, MAPKKKK5
  • Description

    • mitogen-activated protein kinase kinase kinase kinase 5
  • Type of Gene

    • protein-coding
  • Chromosome

    • 14
  • Location

    • 14q11.2-q21
  • RNA Seq 1

    Sample Expression RPKM
    adipose
    3.02
    colon
    1.49
    heart
    4.47
    hypothalamus
    4.14
    kidney
    4.46
    liver
    1.62
    lung
    6.68
    ovary
    12.15
    skeletalmuscle
    2.85
    spleen
    8.94
    testes
    5.15
  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Negative Uncertain
    appendix glandular cells Weak Uncertain
    appendix lymphoid tissue Negative Uncertain
    bone marrow hematopoietic cells Weak Uncertain
    breast glandular cells Negative Uncertain
    bronchus respiratory epithelial cells Negative Uncertain
    cerebellum cells in granular layer Negative Uncertain
    cerebellum cells in molecular layer Negative Uncertain
    cerebellum Purkinje cells Moderate Uncertain
    cerebral cortex glial cells Negative Uncertain
    cerebral cortex neuronal cells Negative Uncertain
    cervix, uterine glandular cells Negative Uncertain
    cervix, uterine squamous epithelial cells Weak Uncertain
    colon glandular cells Moderate Uncertain
    duodenum glandular cells Moderate Uncertain
    epididymis glandular cells Negative Uncertain
    esophagus squamous epithelial cells Moderate Uncertain
    fallopian tube glandular cells Moderate Uncertain
    gall bladder glandular cells Weak Uncertain
    heart muscle myocytes Negative Uncertain
    hippocampus glial cells Negative Uncertain
    hippocampus neuronal cells Negative Uncertain
    kidney cells in glomeruli Weak Uncertain
    kidney cells in tubules Negative Uncertain
    lateral ventricle glial cells Negative Uncertain
    lateral ventricle neuronal cells Negative Uncertain
    liver bile duct cells Negative Uncertain
    liver hepatocytes Negative Uncertain
    lung macrophages Negative Uncertain
    lung pneumocytes Negative Uncertain
    lymph node germinal center cells Negative Uncertain
    lymph node non-germinal center cells Negative Uncertain
    nasopharynx respiratory epithelial cells Weak Uncertain
    oral mucosa squamous epithelial cells Negative Uncertain
    ovary follicle cells Moderate Uncertain
    ovary ovarian stroma cells Negative Uncertain
    pancreas exocrine glandular cells Weak Uncertain
    parathyroid gland glandular cells Negative Uncertain
    placenta trophoblastic cells Negative Uncertain
    prostate glandular cells Negative Uncertain
    rectum glandular cells Weak Uncertain
    salivary gland glandular cells Negative Uncertain
    seminal vesicle glandular cells Weak Uncertain
    skeletal muscle myocytes Moderate Uncertain
    skin epidermal cells Negative Uncertain
    small intestine glandular cells Negative Uncertain
    smooth muscle smooth muscle cells Moderate Uncertain
    spleen cells in red pulp Negative Uncertain
    spleen cells in white pulp Negative Uncertain
    stomach, lower glandular cells Negative Uncertain
    stomach, upper glandular cells Weak Uncertain
    testis cells in seminiferus ducts Moderate Uncertain
    testis Leydig cells Negative Uncertain
    thyroid gland glandular cells Weak Uncertain
    tonsil germinal center cells Negative Uncertain
    tonsil non-germinal center cells Negative Uncertain
    tonsil squamous epithelial cells Weak Uncertain
    urinary bladder urothelial cells Moderate Uncertain
    uterus, post-menopause cells in endometrial stroma Moderate Uncertain
    uterus, post-menopause glandular cells Moderate Uncertain
    uterus, pre-menopause cells in endometrial stroma Negative Uncertain
    uterus, pre-menopause glandular cells Negative Uncertain
    vagina squamous epithelial cells Weak Uncertain
    vulva/anal skin epidermal cells Moderate Uncertain
  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0005737 cytoplasm 18029348 Component
    GO:0005886 plasma membrane 18029348 Component
    GO:0005524 ATP binding 9038372 Function
    GO:0005515 protein binding 17474147 Function
    GO:0004672 protein kinase activity 9038372 Function
    GO:0004674 protein serine/threonine kinase activity 9038372 Function
    GO:0005083 small GTPase regulator activity Function
    GO:0007257 activation of JUN kinase activity 9038372 Process
    GO:0007243 intracellular protein kinase cascade 9038372 Process
    GO:0006468 protein phosphorylation 9038372 Process
    GO:0006950 response to stress 9038372 Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084