Gene: CRK

  • Entrez Gene ID

  • Symbol

    • CRK
  • Synonyms

    • CRKII, p38
  • Description

    • v-crk sarcoma virus CT10 oncogene homolog (avian)
  • Type of Gene

    • protein-coding
  • Chromosome

    • 17
  • Location

    • 17p13.3
  • RNA Seq 1

    Sample Expression RPKM
    adipose
    7.56
    colon
    4.27
    heart
    5.54
    hypothalamus
    6.44
    kidney
    5.27
    liver
    10.29
    lung
    5.61
    ovary
    3.63
    skeletalmuscle
    3.57
    spleen
    5.87
    testes
    6.2
  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Negative Supportive
    appendix glandular cells Weak Supportive
    appendix lymphoid tissue Negative Supportive
    bone marrow hematopoietic cells Negative Supportive
    breast glandular cells Negative Supportive
    bronchus respiratory epithelial cells Weak Supportive
    cerebellum cells in granular layer Negative Supportive
    cerebellum cells in molecular layer Negative Supportive
    cerebellum Purkinje cells Negative Supportive
    cerebral cortex glial cells Negative Supportive
    cerebral cortex neuronal cells Negative Supportive
    cervix, uterine glandular cells Negative Supportive
    cervix, uterine squamous epithelial cells Moderate Supportive
    colon glandular cells Moderate Supportive
    duodenum glandular cells Strong Supportive
    epididymis glandular cells Negative Supportive
    esophagus squamous epithelial cells Moderate Supportive
    fallopian tube glandular cells Negative Supportive
    gall bladder glandular cells Moderate Supportive
    heart muscle myocytes Weak Supportive
    hippocampus glial cells Negative Supportive
    hippocampus neuronal cells Negative Supportive
    kidney cells in glomeruli Negative Supportive
    kidney cells in tubules Strong Supportive
    lateral ventricle glial cells Negative Supportive
    lateral ventricle neuronal cells Negative Supportive
    liver bile duct cells Moderate Supportive
    liver hepatocytes Strong Supportive
    lung macrophages Negative Supportive
    lung pneumocytes Negative Supportive
    lymph node germinal center cells Negative Supportive
    lymph node non-germinal center cells Negative Supportive
    nasopharynx respiratory epithelial cells Weak Supportive
    oral mucosa squamous epithelial cells Moderate Supportive
    ovary ovarian stroma cells Negative Supportive
    pancreas exocrine glandular cells Moderate Supportive
    pancreas islets of Langerhans Weak Supportive
    placenta trophoblastic cells Weak Supportive
    prostate glandular cells Weak Supportive
    rectum glandular cells Weak Supportive
    salivary gland glandular cells Strong Supportive
    seminal vesicle glandular cells Negative Supportive
    skeletal muscle myocytes Moderate Supportive
    skin epidermal cells Moderate Supportive
    small intestine glandular cells Strong Supportive
    smooth muscle smooth muscle cells Negative Supportive
    spleen cells in red pulp Negative Supportive
    spleen cells in white pulp Negative Supportive
    stomach, lower glandular cells Weak Supportive
    stomach, upper glandular cells Negative Supportive
    testis cells in seminiferus ducts Negative Supportive
    testis Leydig cells Negative Supportive
    thyroid gland glandular cells Negative Supportive
    tonsil germinal center cells Negative Supportive
    tonsil non-germinal center cells Negative Supportive
    tonsil squamous epithelial cells Moderate Supportive
    urinary bladder urothelial cells Negative Supportive
    uterus, post-menopause cells in endometrial stroma Negative Supportive
    uterus, post-menopause glandular cells Negative Supportive
    uterus, pre-menopause cells in endometrial stroma Negative Supportive
    uterus, pre-menopause glandular cells Negative Supportive
    vagina squamous epithelial cells Moderate Supportive
    vulva/anal skin epidermal cells Moderate Supportive
  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0005737 cytoplasm 11870224 Component
    GO:0005829 cytosol Component
    GO:0005768 endosome Component
    GO:0005634 nucleus 10748058 Component
    GO:0005886 plasma membrane Component
    GO:0046875 ephrin receptor binding 11870224 Function
    GO:0005515 protein binding 14657239 Function
    GO:0045309 protein phosphorylated amino acid binding Function
    GO:0042169 SH2 domain binding 9472046 Function
    GO:0005070 SH3/SH2 adaptor activity Function
    GO:0000186 activation of MAPKK activity Process
    GO:0007596 blood coagulation Process
    GO:0048013 ephrin receptor signaling pathway 11870224 Process
    GO:0008286 insulin receptor signaling pathway Process
    GO:0048011 nerve growth factor receptor signaling pathway Process
    GO:0030168 platelet activation Process
    GO:0032956 regulation of actin cytoskeleton organization 11870224 Process
    GO:0035020 regulation of Rac protein signal transduction Process
    GO:0032319 regulation of Rho GTPase activity 11870224 Process
    GO:0006357 regulation of transcription from RNA polymerase II promoter 10748058 Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084