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Entrez Gene ID
- 1789 (Go to NCBI)
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Symbol
- DNMT3B
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Synonyms
- ICF, ICF1, M.HsaIIIB
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Description
- DNA (cytosine-5-)-methyltransferase 3 beta
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Type of Gene
- protein-coding
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Chromosome
- 20
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Location
- 20q11.2
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RNA Seq 1
Sample Expression RPKM adipose 0.02 colon 0.12 heart 0.06 hypothalamus 0.02 kidney 0.26 liver 0.01 lung 0.07 ovary 0.08 skeletalmuscle 0.04 spleen 0.06 testes 0.58 -
Protein
Tissue Cell type Staining level Reliability adrenal gland glandular cells Moderate Uncertain appendix glandular cells Moderate Uncertain appendix lymphoid tissue Weak Uncertain bone marrow hematopoietic cells Weak Uncertain breast glandular cells Moderate Uncertain bronchus respiratory epithelial cells Moderate Uncertain cerebellum cells in granular layer Weak Uncertain cerebellum cells in molecular layer Weak Uncertain cerebellum Purkinje cells Weak Uncertain cerebral cortex glial cells Negative Uncertain cerebral cortex neuronal cells Moderate Uncertain cervix, uterine glandular cells Moderate Uncertain cervix, uterine squamous epithelial cells Moderate Uncertain colon glandular cells Moderate Uncertain duodenum glandular cells Moderate Uncertain epididymis glandular cells Moderate Uncertain esophagus squamous epithelial cells Moderate Uncertain fallopian tube glandular cells Moderate Uncertain gall bladder glandular cells Moderate Uncertain heart muscle myocytes Weak Uncertain hippocampus glial cells Negative Uncertain hippocampus neuronal cells Weak Uncertain kidney cells in glomeruli Weak Uncertain kidney cells in tubules Moderate Uncertain lateral ventricle glial cells Weak Uncertain liver bile duct cells Weak Uncertain liver hepatocytes Negative Uncertain lung macrophages Moderate Uncertain lung pneumocytes Weak Uncertain lymph node germinal center cells Weak Uncertain lymph node non-germinal center cells Moderate Uncertain nasopharynx respiratory epithelial cells Moderate Uncertain oral mucosa squamous epithelial cells Moderate Uncertain ovary ovarian stroma cells Weak Uncertain pancreas exocrine glandular cells Moderate Uncertain pancreas islets of Langerhans Moderate Uncertain parathyroid gland glandular cells Weak Uncertain placenta decidual cells Moderate Uncertain placenta trophoblastic cells Strong Uncertain prostate glandular cells Weak Uncertain rectum glandular cells Moderate Uncertain salivary gland glandular cells Weak Uncertain skeletal muscle myocytes Weak Uncertain skin epidermal cells Moderate Uncertain small intestine glandular cells Moderate Uncertain smooth muscle smooth muscle cells Weak Uncertain spleen cells in red pulp Weak Uncertain spleen cells in white pulp Weak Uncertain stomach, lower glandular cells Moderate Uncertain stomach, upper glandular cells Moderate Uncertain testis cells in seminiferus ducts Strong Uncertain testis Leydig cells Moderate Uncertain thyroid gland glandular cells Moderate Uncertain tonsil germinal center cells Weak Uncertain tonsil non-germinal center cells Weak Uncertain tonsil squamous epithelial cells Moderate Uncertain urinary bladder urothelial cells Moderate Uncertain uterus, post-menopause cells in endometrial stroma Weak Uncertain uterus, post-menopause glandular cells Weak Uncertain uterus, pre-menopause cells in endometrial stroma Weak Uncertain uterus, pre-menopause glandular cells Moderate Uncertain vagina squamous epithelial cells Moderate Uncertain vulva/anal skin epidermal cells Moderate Uncertain -
Gene Ontology
GO ID GO term PubMed Category GO:0000775 chromosome, centromeric region Component GO:0005737 cytoplasm Component GO:0043231 intracellular membrane-bounded organelle 18029348 Component GO:0005720 nuclear heterochromatin Component GO:0005730 nucleolus 18029348 Component GO:0005634 nucleus 17303076 Component GO:0003886 DNA (cytosine-5-)-methyltransferase activity 16543361 Function GO:0003886 DNA (cytosine-5-)-methyltransferase activity 10647011 Function GO:0003886 DNA (cytosine-5-)-methyltransferase activity 10433969 Function GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Function GO:0009008 DNA-methyltransferase activity 10325416 Function GO:0046872 metal ion binding Function GO:0005515 protein binding 11735126 Function GO:0003714 transcription corepressor activity 17303076 Function GO:0003714 transcription corepressor activity 18567530 Function GO:0045322 unmethylated CpG binding Function GO:0071230 cellular response to amino acid stimulus Process GO:0006306 DNA methylation 10555141 Process GO:0006306 DNA methylation 10433969 Process GO:0043045 DNA methylation involved in embryo development Process GO:0010424 DNA methylation on cytosine within a CG sequence Process GO:0006346 methylation-dependent chromatin silencing Process GO:0051573 negative regulation of histone H3-K9 methylation 18413740 Process GO:0000122 negative regulation of transcription from RNA polymerase II promoter 17303076 Process GO:0010628 positive regulation of gene expression 18413740 Process GO:0051571 positive regulation of histone H3-K4 methylation 18413740 Process GO:0045666 positive regulation of neuron differentiation Process GO:0031503 protein complex localization Process GO:0006349 regulation of gene expression by genetic imprinting Process GO:0042493 response to drug Process GO:0010212 response to ionizing radiation Process GO:0046498 S-adenosylhomocysteine metabolic process Process GO:0046499 S-adenosylmethioninamine metabolic process Process
- Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084