Gene: DNMT3B

  • Entrez Gene ID

  • Symbol

    • DNMT3B

  • Synonyms

    • ICF, ICF1, M.HsaIIIB

  • Description

    • DNA (cytosine-5-)-methyltransferase 3 beta

  • Type of Gene

    • protein-coding

  • Chromosome

    • 20

  • Location

    • 20q11.2

  • RNA Seq 1

    Sample Expression RPKM
    adipose
    		0.02
    colon
    		0.12
    heart
    		0.06
    hypothalamus
    		0.02
    kidney
    		0.26
    liver
    		0.01
    lung
    		0.07
    ovary
    		0.08
    skeletalmuscle
    		0.04
    spleen
    		0.06
    testes
    		0.58

  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Moderate Uncertain
    appendix glandular cells Moderate Uncertain
    appendix lymphoid tissue Weak Uncertain
    bone marrow hematopoietic cells Weak Uncertain
    breast glandular cells Moderate Uncertain
    bronchus respiratory epithelial cells Moderate Uncertain
    cerebellum cells in granular layer Weak Uncertain
    cerebellum cells in molecular layer Weak Uncertain
    cerebellum Purkinje cells Weak Uncertain
    cerebral cortex glial cells Negative Uncertain
    cerebral cortex neuronal cells Moderate Uncertain
    cervix, uterine glandular cells Moderate Uncertain
    cervix, uterine squamous epithelial cells Moderate Uncertain
    colon glandular cells Moderate Uncertain
    duodenum glandular cells Moderate Uncertain
    epididymis glandular cells Moderate Uncertain
    esophagus squamous epithelial cells Moderate Uncertain
    fallopian tube glandular cells Moderate Uncertain
    gall bladder glandular cells Moderate Uncertain
    heart muscle myocytes Weak Uncertain
    hippocampus glial cells Negative Uncertain
    hippocampus neuronal cells Weak Uncertain
    kidney cells in glomeruli Weak Uncertain
    kidney cells in tubules Moderate Uncertain
    lateral ventricle glial cells Weak Uncertain
    liver bile duct cells Weak Uncertain
    liver hepatocytes Negative Uncertain
    lung macrophages Moderate Uncertain
    lung pneumocytes Weak Uncertain
    lymph node germinal center cells Weak Uncertain
    lymph node non-germinal center cells Moderate Uncertain
    nasopharynx respiratory epithelial cells Moderate Uncertain
    oral mucosa squamous epithelial cells Moderate Uncertain
    ovary ovarian stroma cells Weak Uncertain
    pancreas exocrine glandular cells Moderate Uncertain
    pancreas islets of Langerhans Moderate Uncertain
    parathyroid gland glandular cells Weak Uncertain
    placenta decidual cells Moderate Uncertain
    placenta trophoblastic cells Strong Uncertain
    prostate glandular cells Weak Uncertain
    rectum glandular cells Moderate Uncertain
    salivary gland glandular cells Weak Uncertain
    skeletal muscle myocytes Weak Uncertain
    skin epidermal cells Moderate Uncertain
    small intestine glandular cells Moderate Uncertain
    smooth muscle smooth muscle cells Weak Uncertain
    spleen cells in red pulp Weak Uncertain
    spleen cells in white pulp Weak Uncertain
    stomach, lower glandular cells Moderate Uncertain
    stomach, upper glandular cells Moderate Uncertain
    testis cells in seminiferus ducts Strong Uncertain
    testis Leydig cells Moderate Uncertain
    thyroid gland glandular cells Moderate Uncertain
    tonsil germinal center cells Weak Uncertain
    tonsil non-germinal center cells Weak Uncertain
    tonsil squamous epithelial cells Moderate Uncertain
    urinary bladder urothelial cells Moderate Uncertain
    uterus, post-menopause cells in endometrial stroma Weak Uncertain
    uterus, post-menopause glandular cells Weak Uncertain
    uterus, pre-menopause cells in endometrial stroma Weak Uncertain
    uterus, pre-menopause glandular cells Moderate Uncertain
    vagina squamous epithelial cells Moderate Uncertain
    vulva/anal skin epidermal cells Moderate Uncertain

  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0000775 chromosome, centromeric region Component
    GO:0005737 cytoplasm Component
    GO:0043231 intracellular membrane-bounded organelle 18029348 Component
    GO:0005720 nuclear heterochromatin Component
    GO:0005730 nucleolus 18029348 Component
    GO:0005634 nucleus 17303076 Component
    GO:0003886 DNA (cytosine-5-)-methyltransferase activity 16543361 Function
    GO:0003886 DNA (cytosine-5-)-methyltransferase activity 10647011 Function
    GO:0003886 DNA (cytosine-5-)-methyltransferase activity 10433969 Function
    GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Function
    GO:0009008 DNA-methyltransferase activity 10325416 Function
    GO:0046872 metal ion binding Function
    GO:0005515 protein binding 11735126 Function
    GO:0003714 transcription corepressor activity 17303076 Function
    GO:0003714 transcription corepressor activity 18567530 Function
    GO:0045322 unmethylated CpG binding Function
    GO:0071230 cellular response to amino acid stimulus Process
    GO:0006306 DNA methylation 10555141 Process
    GO:0006306 DNA methylation 10433969 Process
    GO:0043045 DNA methylation involved in embryo development Process
    GO:0010424 DNA methylation on cytosine within a CG sequence Process
    GO:0006346 methylation-dependent chromatin silencing Process
    GO:0051573 negative regulation of histone H3-K9 methylation 18413740 Process
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter 17303076 Process
    GO:0010628 positive regulation of gene expression 18413740 Process
    GO:0051571 positive regulation of histone H3-K4 methylation 18413740 Process
    GO:0045666 positive regulation of neuron differentiation Process
    GO:0031503 protein complex localization Process
    GO:0006349 regulation of gene expression by genetic imprinting Process
    GO:0042493 response to drug Process
    GO:0010212 response to ionizing radiation Process
    GO:0046498 S-adenosylhomocysteine metabolic process Process
    GO:0046499 S-adenosylmethioninamine metabolic process Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084