Gene: RHOA

  • Entrez Gene ID

  • Symbol

    • RHOA

  • Synonyms

    • ARH12, ARHA, RHO12, RHOH12

  • Description

    • ras homolog family member A

  • Type of Gene

    • protein-coding

  • Chromosome

    • 3

  • Location

    • 3p21.3

  • RNA Seq 1

    Sample Expression RPKM
    adipose
    		65.99
    colon
    		28.28
    heart
    		31.69
    hypothalamus
    		27.3
    kidney
    		31.44
    liver
    		25.35
    lung
    		56.68
    ovary
    		17.5
    skeletalmuscle
    		24.32
    spleen
    		55.1
    testes
    		41.94

  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Moderate Uncertain
    appendix glandular cells Weak Uncertain
    appendix lymphoid tissue Weak Uncertain
    bone marrow hematopoietic cells Weak Uncertain
    breast glandular cells Weak Uncertain
    bronchus respiratory epithelial cells Weak Uncertain
    cerebellum cells in granular layer Weak Uncertain
    cerebellum cells in molecular layer Moderate Uncertain
    cerebellum Purkinje cells Weak Uncertain
    cerebral cortex glial cells Moderate Uncertain
    cerebral cortex neuronal cells Moderate Uncertain
    cervix, uterine glandular cells Weak Uncertain
    cervix, uterine squamous epithelial cells Negative Uncertain
    colon glandular cells Weak Uncertain
    duodenum glandular cells Moderate Uncertain
    epididymis glandular cells Weak Uncertain
    esophagus squamous epithelial cells Negative Uncertain
    fallopian tube glandular cells Weak Uncertain
    gall bladder glandular cells Weak Uncertain
    heart muscle myocytes Negative Uncertain
    hippocampus glial cells Moderate Uncertain
    hippocampus neuronal cells Moderate Uncertain
    kidney cells in glomeruli Weak Uncertain
    kidney cells in tubules Weak Uncertain
    lateral ventricle glial cells Moderate Uncertain
    liver bile duct cells Negative Uncertain
    liver hepatocytes Negative Uncertain
    lung macrophages Moderate Uncertain
    lung pneumocytes Weak Uncertain
    lymph node germinal center cells Weak Uncertain
    lymph node non-germinal center cells Moderate Uncertain
    nasopharynx respiratory epithelial cells Moderate Uncertain
    oral mucosa squamous epithelial cells Negative Uncertain
    ovary ovarian stroma cells Weak Uncertain
    pancreas exocrine glandular cells Weak Uncertain
    pancreas islets of Langerhans Moderate Uncertain
    parathyroid gland glandular cells Weak Uncertain
    placenta decidual cells Weak Uncertain
    placenta trophoblastic cells Moderate Uncertain
    prostate glandular cells Weak Uncertain
    rectum glandular cells Moderate Uncertain
    salivary gland glandular cells Weak Uncertain
    seminal vesicle glandular cells Weak Uncertain
    skeletal muscle myocytes Negative Uncertain
    skin epidermal cells Negative Uncertain
    small intestine glandular cells Weak Uncertain
    smooth muscle smooth muscle cells Negative Uncertain
    spleen cells in red pulp Weak Uncertain
    spleen cells in white pulp Weak Uncertain
    stomach, lower glandular cells Moderate Uncertain
    stomach, upper glandular cells Moderate Uncertain
    testis cells in seminiferus ducts Moderate Uncertain
    testis Leydig cells Weak Uncertain
    thyroid gland glandular cells Moderate Uncertain
    tonsil germinal center cells Weak Uncertain
    tonsil non-germinal center cells Moderate Uncertain
    tonsil squamous epithelial cells Weak Uncertain
    urinary bladder urothelial cells Moderate Uncertain
    uterus, post-menopause cells in endometrial stroma Weak Uncertain
    uterus, post-menopause glandular cells Weak Uncertain
    uterus, pre-menopause cells in endometrial stroma Weak Uncertain
    uterus, pre-menopause glandular cells Weak Uncertain
    vagina squamous epithelial cells Negative Uncertain
    vulva/anal skin epidermal cells Negative Uncertain

  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0043296 apical junction complex Component
    GO:0005938 cell cortex 16103226 Component
    GO:0030054 cell junction Component
    GO:0032154 cleavage furrow Component
    GO:0005856 cytoskeleton Component
    GO:0005829 cytosol Component
    GO:0030027 lamellipodium Component
    GO:0030496 midbody Component
    GO:0005739 mitochondrion Component
    GO:0005634 nucleus Component
    GO:0005886 plasma membrane Component
    GO:0032587 ruffle membrane Component
    GO:0005525 GTP binding Function
    GO:0003924 GTPase activity 10436159 Function
    GO:0017022 myosin binding 15644318 Function
    GO:0005515 protein binding 10051605 Function
    GO:0030036 actin cytoskeleton organization 10436159 Process
    GO:0030521 androgen receptor signaling pathway Process
    GO:0043297 apical junction assembly Process
    GO:0007411 axon guidance Process
    GO:0007596 blood coagulation Process
    GO:0007160 cell-matrix adhesion Process
    GO:0036089 cleavage furrow formation 16103226 Process
    GO:0050771 negative regulation of axonogenesis Process
    GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway Process
    GO:0043524 negative regulation of neuron apoptotic process Process
    GO:0048011 nerve growth factor receptor signaling pathway Process
    GO:0043931 ossification involved in bone maturation Process
    GO:0048015 phosphatidylinositol-mediated signaling Process
    GO:0030168 platelet activation Process
    GO:0050772 positive regulation of axonogenesis Process
    GO:0071777 positive regulation of cell cycle cytokinesis 16103226 Process
    GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade 12761501 Process
    GO:0045666 positive regulation of neuron differentiation 17488780 Process
    GO:0042346 positive regulation of NF-kappaB import into nucleus 12761501 Process
    GO:0051496 positive regulation of stress fiber assembly 15467718 Process
    GO:0050770 regulation of axonogenesis Process
    GO:0030334 regulation of cell migration 19934221 Process
    GO:0033688 regulation of osteoblast proliferation Process
    GO:0051056 regulation of small GTPase mediated signal transduction Process
    GO:0006357 regulation of transcription from RNA polymerase II promoter Process
    GO:0007266 Rho protein signal transduction 10436159 Process
    GO:0007519 skeletal muscle tissue development Process
    GO:0007264 small GTPase mediated signal transduction Process
    GO:0090307 spindle assembly involved in mitosis 19635168 Process
    GO:0043149 stress fiber assembly Process
    GO:0061383 trabecula morphogenesis Process
    GO:0007179 transforming growth factor beta receptor signaling pathway Process
    GO:0019048 virus-host interaction Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084