CellFinder · Gene

Gene: SMAD4

Entrez Gene ID
- 4089 (Go to NCBI)
Symbol
- SMAD4
Synonyms
- DPC4, JIP, MADH4, MYHRS
Description
- SMAD family member 4
Type of Gene
- protein-coding
Chromosome
- 18
Location
- 18q21.1

RNA Seq ¹

Sample	Expression	RPKM
adipose		2.5
colon		3.23
heart		3.99
hypothalamus		2.87
kidney		3.89
liver		3.32
lung		3.59
ovary		7.49
skeletalmuscle		6.34
spleen		5.76
testes		5.31

Gene Ontology

GO ID	GO term	PubMed	Category
GO:0032444	activin responsive factor complex	9389648	Component
GO:0005813	centrosome	18029348	Component
GO:0005737	cytoplasm	12161428	Component
GO:0005829	cytosol		Component
GO:0005730	nucleolus	18029348	Component
GO:0005654	nucleoplasm		Component
GO:0005634	nucleus	12161428	Component
GO:0071141	SMAD protein complex	18832382	Component
GO:0005667	transcription factor complex	17438144	Component
GO:0005667	transcription factor complex	12374795	Component
GO:0003682	chromatin binding		Function
GO:0005518	collagen binding		Function
GO:0000987	core promoter proximal region sequence-specific DNA binding	18832382	Function
GO:0003677	DNA binding	9389648	Function
GO:0070411	I-SMAD binding	9256479	Function
GO:0042802	identical protein binding	9111321	Function
GO:0005515	protein binding	11278302	Function
GO:0000988	protein binding transcription factor activity	18832382	Function
GO:0042803	protein homodimerization activity	8774881	Function
GO:0070412	R-SMAD binding	8774881	Function
GO:0043565	sequence-specific DNA binding	10823886	Function
GO:0003700	sequence-specific DNA binding transcription factor activity	10823886	Function
GO:0044212	transcription regulatory region DNA binding	17438144	Function
GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	9389648	Function
GO:0030509	BMP signaling pathway	9389648	Process
GO:0030509	BMP signaling pathway		Process
GO:0001658	branching involved in ureteric bud morphogenesis		Process
GO:0008283	cell proliferation		Process
GO:0048589	developmental growth		Process
GO:0007492	endoderm development		Process
GO:0048859	formation of anatomical boundary		Process
GO:0001702	gastrulation with mouth forming second		Process
GO:0010467	gene expression		Process
GO:0001701	in utero embryonic development		Process
GO:0007498	mesoderm development		Process
GO:0072133	metanephric mesenchyme morphogenesis		Process
GO:0060548	negative regulation of cell death		Process
GO:0030308	negative regulation of cell growth	8774881	Process
GO:0008285	negative regulation of cell proliferation		Process
GO:0042177	negative regulation of protein catabolic process		Process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter		Process
GO:0045892	negative regulation of transcription, DNA-dependent	8774881	Process
GO:0072134	nephrogenic mesenchyme morphogenesis		Process
GO:0014033	neural crest cell differentiation		Process
GO:0048663	neuron fate commitment		Process
GO:0060021	palate development		Process
GO:0030513	positive regulation of BMP signaling pathway	19366699	Process
GO:0010718	positive regulation of epithelial to mesenchymal transition		Process
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation		Process
GO:0060391	positive regulation of SMAD protein import into nucleus		Process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	18832382	Process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter		Process
GO:0045893	positive regulation of transcription, DNA-dependent	8774881	Process
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	19328798	Process
GO:0051098	regulation of binding		Process
GO:0051797	regulation of hair follicle development		Process
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	8774881	Process
GO:0032909	regulation of transforming growth factor beta2 production	12411310	Process
GO:0001666	response to hypoxia	12411310	Process
GO:0071559	response to transforming growth factor beta stimulus	9707553	Process
GO:0048733	sebaceous gland development		Process
GO:0007183	SMAD protein complex assembly	10823886	Process
GO:0060395	SMAD protein signal transduction	9707553	Process
GO:0032525	somite rostral/caudal axis specification		Process
GO:0006367	transcription initiation from RNA polymerase II promoter		Process
GO:0006351	transcription, DNA-dependent		Process
GO:0007179	transforming growth factor beta receptor signaling pathway	9389648	Process
GO:0007179	transforming growth factor beta receptor signaling pathway		Process

Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084

Gene: SMAD4

Entrez Gene ID

Symbol

Synonyms

Description

Type of Gene

Chromosome

Location

RNA Seq 1

Gene Ontology

RNA Seq ¹