Gene: MAP4K2

  • Entrez Gene ID

  • Symbol

    • MAP4K2
  • Synonyms

    • BL44, GCK, RAB8IP
  • Description

    • mitogen-activated protein kinase kinase kinase kinase 2
  • Type of Gene

    • protein-coding
  • Chromosome

    • 11
  • Location

    • 11q13
  • RNA Seq 1

    Sample Expression RPKM
    adipose
    0.26
    colon
    0.37
    heart
    0.12
    hypothalamus
    0.83
    kidney
    0.26
    liver
    0.07
    lung
    0.55
    ovary
    0.18
    skeletalmuscle
    0.08
    spleen
    1.04
    testes
    0.45
  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Moderate Supportive
    appendix glandular cells Moderate Supportive
    bone marrow hematopoietic cells Moderate Supportive
    breast glandular cells Weak Supportive
    bronchus respiratory epithelial cells Moderate Supportive
    cerebellum cells in granular layer Moderate Supportive
    cerebellum cells in molecular layer Moderate Supportive
    cerebellum Purkinje cells Moderate Supportive
    cerebral cortex glial cells Negative Supportive
    cerebral cortex neuronal cells Strong Supportive
    cervix, uterine glandular cells Weak Supportive
    colon glandular cells Moderate Supportive
    duodenum glandular cells Moderate Supportive
    epididymis glandular cells Moderate Supportive
    fallopian tube glandular cells Moderate Supportive
    gall bladder glandular cells Moderate Supportive
    heart muscle myocytes Moderate Supportive
    hippocampus glial cells Weak Supportive
    hippocampus neuronal cells Moderate Supportive
    kidney cells in glomeruli Moderate Supportive
    kidney cells in tubules Moderate Supportive
    lateral ventricle glial cells Moderate Supportive
    liver bile duct cells Moderate Supportive
    liver hepatocytes Weak Supportive
    lung macrophages Strong Supportive
    lung pneumocytes Weak Supportive
    lymph node germinal center cells Strong Supportive
    lymph node non-germinal center cells Moderate Supportive
    nasopharynx respiratory epithelial cells Moderate Supportive
    oral mucosa squamous epithelial cells Moderate Supportive
    ovary ovarian stroma cells Weak Supportive
    pancreas exocrine glandular cells Weak Supportive
    pancreas islets of Langerhans Weak Supportive
    placenta decidual cells Weak Supportive
    placenta trophoblastic cells Moderate Supportive
    prostate glandular cells Moderate Supportive
    rectum glandular cells Moderate Supportive
    salivary gland glandular cells Weak Supportive
    seminal vesicle glandular cells Strong Supportive
    skeletal muscle myocytes Moderate Supportive
    skin epidermal cells Moderate Supportive
    small intestine glandular cells Moderate Supportive
    smooth muscle smooth muscle cells Weak Supportive
    spleen cells in red pulp Weak Supportive
    spleen cells in white pulp Moderate Supportive
    stomach, lower glandular cells Moderate Supportive
    stomach, upper glandular cells Moderate Supportive
    testis cells in seminiferus ducts Strong Supportive
    testis Leydig cells Weak Supportive
    thyroid gland glandular cells Moderate Supportive
    tonsil germinal center cells Strong Supportive
    tonsil non-germinal center cells Strong Supportive
    tonsil squamous epithelial cells Moderate Supportive
    urinary bladder urothelial cells Moderate Supportive
    uterus, post-menopause cells in endometrial stroma Weak Supportive
    uterus, post-menopause glandular cells Moderate Supportive
    uterus, pre-menopause cells in endometrial stroma Weak Supportive
    uterus, pre-menopause glandular cells Moderate Supportive
    vulva/anal skin epidermal cells Weak Supportive
  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0016323 basolateral plasma membrane Component
    GO:0000139 Golgi membrane Component
    GO:0005524 ATP binding 11784851 Function
    GO:0031435 mitogen-activated protein kinase kinase kinase binding 17584736 Function
    GO:0005515 protein binding 11784851 Function
    GO:0004674 protein serine/threonine kinase activity 11784851 Function
    GO:0005083 small GTPase regulator activity Function
    GO:0007257 activation of JUN kinase activity 17584736 Process
    GO:0006955 immune response 7515885 Process
    GO:0045087 innate immune response Process
    GO:0007243 intracellular protein kinase cascade 11784851 Process
    GO:0007254 JNK cascade 7477268 Process
    GO:0046330 positive regulation of JNK cascade 17584736 Process
    GO:0006468 protein phosphorylation 11784851 Process
    GO:0006950 response to stress 8643544 Process
    GO:0006903 vesicle targeting Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084