Gene: BCL2L1

  • Entrez Gene ID

  • Symbol

    • BCL2L1

  • Synonyms

    • BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS

  • Description

    • BCL2-like 1

  • Type of Gene

    • protein-coding

  • Chromosome

    • 20

  • Location

    • 20q11.21

  • RNA Seq 1

    Sample Expression RPKM
    adipose
    		3.57
    colon
    		3.76
    heart
    		4.16
    hypothalamus
    		6.73
    kidney
    		8.39
    liver
    		5.14
    lung
    		7.38
    ovary
    		1.73
    skeletalmuscle
    		3.33
    spleen
    		5.73
    testes
    		3.95

  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Negative Uncertain
    appendix glandular cells Negative Uncertain
    appendix lymphoid tissue Negative Uncertain
    bone marrow hematopoietic cells Weak Uncertain
    breast glandular cells Negative Uncertain
    bronchus respiratory epithelial cells Negative Uncertain
    cerebellum cells in granular layer Negative Uncertain
    cerebellum cells in molecular layer Negative Uncertain
    cerebellum Purkinje cells Negative Uncertain
    cerebral cortex glial cells Negative Uncertain
    cerebral cortex neuronal cells Negative Uncertain
    cervix, uterine glandular cells Negative Uncertain
    cervix, uterine squamous epithelial cells Negative Uncertain
    colon glandular cells Negative Uncertain
    duodenum glandular cells Negative Uncertain
    esophagus squamous epithelial cells Negative Uncertain
    fallopian tube glandular cells Negative Uncertain
    gall bladder glandular cells Weak Uncertain
    heart muscle myocytes Negative Uncertain
    hippocampus glial cells Negative Uncertain
    hippocampus neuronal cells Negative Uncertain
    kidney cells in glomeruli Negative Uncertain
    kidney cells in tubules Negative Uncertain
    lateral ventricle glial cells Negative Uncertain
    lateral ventricle neuronal cells Negative Uncertain
    liver bile duct cells Negative Uncertain
    liver hepatocytes Negative Uncertain
    lung macrophages Weak Uncertain
    lung pneumocytes Negative Uncertain
    lymph node germinal center cells Negative Uncertain
    lymph node non-germinal center cells Negative Uncertain
    nasopharynx respiratory epithelial cells Weak Uncertain
    oral mucosa squamous epithelial cells Negative Uncertain
    ovary ovarian stroma cells Negative Uncertain
    pancreas exocrine glandular cells Negative Uncertain
    parathyroid gland glandular cells Negative Uncertain
    placenta decidual cells Negative Uncertain
    placenta trophoblastic cells Negative Uncertain
    prostate glandular cells Weak Uncertain
    rectum glandular cells Weak Uncertain
    salivary gland glandular cells Negative Uncertain
    seminal vesicle glandular cells Negative Uncertain
    skeletal muscle myocytes Negative Uncertain
    skin epidermal cells Negative Uncertain
    small intestine glandular cells Negative Uncertain
    smooth muscle smooth muscle cells Negative Uncertain
    spleen cells in red pulp Negative Uncertain
    spleen cells in white pulp Negative Uncertain
    stomach, lower glandular cells Negative Uncertain
    stomach, upper glandular cells Weak Uncertain
    testis cells in seminiferus ducts Negative Uncertain
    testis Leydig cells Negative Uncertain
    thyroid gland glandular cells Negative Uncertain
    tonsil germinal center cells Weak Uncertain
    tonsil non-germinal center cells Negative Uncertain
    tonsil squamous epithelial cells Negative Uncertain
    uterus, post-menopause cells in endometrial stroma Negative Uncertain
    uterus, post-menopause glandular cells Negative Uncertain
    uterus, pre-menopause cells in endometrial stroma Negative Uncertain
    uterus, pre-menopause glandular cells Negative Uncertain
    vagina squamous epithelial cells Negative Uncertain
    vulva/anal skin epidermal cells Negative Uncertain

  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0097136 Bcl-2 family protein complex Component
    GO:0005813 centrosome Component
    GO:0005737 cytoplasm Component
    GO:0005829 cytosol Component
    GO:0016021 integral to membrane Component
    GO:0005741 mitochondrial outer membrane 12667443 Component
    GO:0005741 mitochondrial outer membrane Component
    GO:0005739 mitochondrion 12011449 Component
    GO:0031965 nuclear membrane Component
    GO:0051434 BH3 domain binding 15901672 Function
    GO:0042802 identical protein binding 15131699 Function
    GO:0005515 protein binding 10837489 Function
    GO:0046982 protein heterodimerization activity Function
    GO:0019901 protein kinase binding Function
    GO:0008637 apoptotic mitochondrial changes 9393856 Process
    GO:0006915 apoptotic process Process
    GO:0008283 cell proliferation Process
    GO:0060154 cellular process regulating host cell cycle in response to virus Process
    GO:0071312 cellular response to alkaloid Process
    GO:0071230 cellular response to amino acid stimulus Process
    GO:0071480 cellular response to gamma radiation Process
    GO:0000910 cytokinesis Process
    GO:0009566 fertilization Process
    GO:0007281 germ cell development Process
    GO:0040007 growth Process
    GO:0001701 in utero embryonic development Process
    GO:0045087 innate immune response Process
    GO:0008584 male gonad development Process
    GO:0071780 mitotic cell cycle G2/M transition checkpoint Process
    GO:0043066 negative regulation of apoptotic process 15231831 Process
    GO:0043066 negative regulation of apoptotic process 17289999 Process
    GO:0090005 negative regulation of establishment of protein localization to plasma membrane Process
    GO:2001243 negative regulation of intrinsic apoptotic signaling pathway Process
    GO:0043524 negative regulation of neuron apoptotic process Process
    GO:0090201 negative regulation of release of cytochrome c from mitochondria Process
    GO:0090201 negative regulation of release of cytochrome c from mitochondria 12667443 Process
    GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Process
    GO:0001541 ovarian follicle development Process
    GO:0008284 positive regulation of cell proliferation Process
    GO:0046902 regulation of mitochondrial membrane permeability 9843949 Process
    GO:0051881 regulation of mitochondrial membrane potential 9843949 Process
    GO:0001836 release of cytochrome c from mitochondria 9843949 Process
    GO:0046898 response to cycloheximide Process
    GO:0034097 response to cytokine stimulus 9184696 Process
    GO:0007283 spermatogenesis Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084