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Entrez Gene ID
- 598 (Go to NCBI)
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Symbol
- BCL2L1
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Synonyms
- BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS
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Description
- BCL2-like 1
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Type of Gene
- protein-coding
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Chromosome
- 20
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Location
- 20q11.21
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RNA Seq 1
Sample Expression RPKM adipose 3.57 colon 3.76 heart 4.16 hypothalamus 6.73 kidney 8.39 liver 5.14 lung 7.38 ovary 1.73 skeletalmuscle 3.33 spleen 5.73 testes 3.95 -
Protein
Tissue Cell type Staining level Reliability adrenal gland glandular cells Negative Uncertain appendix glandular cells Negative Uncertain appendix lymphoid tissue Negative Uncertain bone marrow hematopoietic cells Weak Uncertain breast glandular cells Negative Uncertain bronchus respiratory epithelial cells Negative Uncertain cerebellum cells in granular layer Negative Uncertain cerebellum cells in molecular layer Negative Uncertain cerebellum Purkinje cells Negative Uncertain cerebral cortex glial cells Negative Uncertain cerebral cortex neuronal cells Negative Uncertain cervix, uterine glandular cells Negative Uncertain cervix, uterine squamous epithelial cells Negative Uncertain colon glandular cells Negative Uncertain duodenum glandular cells Negative Uncertain esophagus squamous epithelial cells Negative Uncertain fallopian tube glandular cells Negative Uncertain gall bladder glandular cells Weak Uncertain heart muscle myocytes Negative Uncertain hippocampus glial cells Negative Uncertain hippocampus neuronal cells Negative Uncertain kidney cells in glomeruli Negative Uncertain kidney cells in tubules Negative Uncertain lateral ventricle glial cells Negative Uncertain lateral ventricle neuronal cells Negative Uncertain liver bile duct cells Negative Uncertain liver hepatocytes Negative Uncertain lung macrophages Weak Uncertain lung pneumocytes Negative Uncertain lymph node germinal center cells Negative Uncertain lymph node non-germinal center cells Negative Uncertain nasopharynx respiratory epithelial cells Weak Uncertain oral mucosa squamous epithelial cells Negative Uncertain ovary ovarian stroma cells Negative Uncertain pancreas exocrine glandular cells Negative Uncertain parathyroid gland glandular cells Negative Uncertain placenta decidual cells Negative Uncertain placenta trophoblastic cells Negative Uncertain prostate glandular cells Weak Uncertain rectum glandular cells Weak Uncertain salivary gland glandular cells Negative Uncertain seminal vesicle glandular cells Negative Uncertain skeletal muscle myocytes Negative Uncertain skin epidermal cells Negative Uncertain small intestine glandular cells Negative Uncertain smooth muscle smooth muscle cells Negative Uncertain spleen cells in red pulp Negative Uncertain spleen cells in white pulp Negative Uncertain stomach, lower glandular cells Negative Uncertain stomach, upper glandular cells Weak Uncertain testis cells in seminiferus ducts Negative Uncertain testis Leydig cells Negative Uncertain thyroid gland glandular cells Negative Uncertain tonsil germinal center cells Weak Uncertain tonsil non-germinal center cells Negative Uncertain tonsil squamous epithelial cells Negative Uncertain uterus, post-menopause cells in endometrial stroma Negative Uncertain uterus, post-menopause glandular cells Negative Uncertain uterus, pre-menopause cells in endometrial stroma Negative Uncertain uterus, pre-menopause glandular cells Negative Uncertain vagina squamous epithelial cells Negative Uncertain vulva/anal skin epidermal cells Negative Uncertain -
Gene Ontology
GO ID GO term PubMed Category GO:0097136 Bcl-2 family protein complex Component GO:0005813 centrosome Component GO:0005737 cytoplasm Component GO:0005829 cytosol Component GO:0016021 integral to membrane Component GO:0005741 mitochondrial outer membrane 12667443 Component GO:0005741 mitochondrial outer membrane Component GO:0005739 mitochondrion 12011449 Component GO:0031965 nuclear membrane Component GO:0051434 BH3 domain binding 15901672 Function GO:0042802 identical protein binding 15131699 Function GO:0005515 protein binding 10837489 Function GO:0046982 protein heterodimerization activity Function GO:0019901 protein kinase binding Function GO:0008637 apoptotic mitochondrial changes 9393856 Process GO:0006915 apoptotic process Process GO:0008283 cell proliferation Process GO:0060154 cellular process regulating host cell cycle in response to virus Process GO:0071312 cellular response to alkaloid Process GO:0071230 cellular response to amino acid stimulus Process GO:0071480 cellular response to gamma radiation Process GO:0000910 cytokinesis Process GO:0009566 fertilization Process GO:0007281 germ cell development Process GO:0040007 growth Process GO:0001701 in utero embryonic development Process GO:0045087 innate immune response Process GO:0008584 male gonad development Process GO:0071780 mitotic cell cycle G2/M transition checkpoint Process GO:0043066 negative regulation of apoptotic process 15231831 Process GO:0043066 negative regulation of apoptotic process 17289999 Process GO:0090005 negative regulation of establishment of protein localization to plasma membrane Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway Process GO:0043524 negative regulation of neuron apoptotic process Process GO:0090201 negative regulation of release of cytochrome c from mitochondria Process GO:0090201 negative regulation of release of cytochrome c from mitochondria 12667443 Process GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Process GO:0001541 ovarian follicle development Process GO:0008284 positive regulation of cell proliferation Process GO:0046902 regulation of mitochondrial membrane permeability 9843949 Process GO:0051881 regulation of mitochondrial membrane potential 9843949 Process GO:0001836 release of cytochrome c from mitochondria 9843949 Process GO:0046898 response to cycloheximide Process GO:0034097 response to cytokine stimulus 9184696 Process GO:0007283 spermatogenesis Process
- Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084