-
Entrez Gene ID
- 998 (Go to NCBI)
-
Symbol
- CDC42
-
Synonyms
- CDC42Hs, G25K
-
Description
- cell division cycle 42 (GTP binding protein, 25kDa)
-
Type of Gene
- protein-coding
-
Chromosome
- 1
-
Location
- 1p36.1
-
RNA Seq 1
Sample Expression RPKM adipose 32.11 colon 21.67 heart 22.69 hypothalamus 35.68 kidney 26.3 liver 28.17 lung 30.51 ovary 17.03 skeletalmuscle 12.38 spleen 39.62 testes 23.48 -
Protein
Tissue Cell type Staining level Reliability adrenal gland glandular cells Moderate Uncertain appendix glandular cells Moderate Uncertain appendix lymphoid tissue Moderate Uncertain bone marrow hematopoietic cells Moderate Uncertain breast glandular cells Moderate Uncertain bronchus respiratory epithelial cells Moderate Uncertain cerebellum cells in granular layer Negative Uncertain cerebellum cells in molecular layer Weak Uncertain cerebellum Purkinje cells Moderate Uncertain cerebral cortex glial cells Weak Uncertain cerebral cortex neuronal cells Moderate Uncertain cervix, uterine glandular cells Moderate Uncertain cervix, uterine squamous epithelial cells Weak Uncertain colon glandular cells Moderate Uncertain duodenum glandular cells Moderate Uncertain epididymis glandular cells Moderate Uncertain esophagus squamous epithelial cells Moderate Uncertain fallopian tube glandular cells Moderate Uncertain gall bladder glandular cells Moderate Uncertain heart muscle myocytes Weak Uncertain hippocampus glial cells Moderate Uncertain hippocampus neuronal cells Moderate Uncertain kidney cells in glomeruli Moderate Uncertain kidney cells in tubules Moderate Uncertain lateral ventricle glial cells Weak Uncertain liver bile duct cells Moderate Uncertain liver hepatocytes Weak Uncertain lung macrophages Moderate Uncertain lung pneumocytes Moderate Uncertain lymph node germinal center cells Moderate Uncertain lymph node non-germinal center cells Moderate Uncertain nasopharynx respiratory epithelial cells Moderate Uncertain oral mucosa squamous epithelial cells Moderate Uncertain ovary ovarian stroma cells Weak Uncertain pancreas exocrine glandular cells Strong Uncertain pancreas islets of Langerhans Strong Uncertain parathyroid gland glandular cells Moderate Uncertain placenta decidual cells Moderate Uncertain placenta trophoblastic cells Strong Uncertain prostate glandular cells Moderate Uncertain rectum glandular cells Moderate Uncertain salivary gland glandular cells Moderate Uncertain seminal vesicle glandular cells Moderate Uncertain skeletal muscle myocytes Strong Uncertain skin epidermal cells Moderate Uncertain small intestine glandular cells Moderate Uncertain smooth muscle smooth muscle cells Weak Uncertain spleen cells in red pulp Moderate Uncertain spleen cells in white pulp Moderate Uncertain stomach, lower glandular cells Moderate Uncertain stomach, upper glandular cells Moderate Uncertain testis cells in seminiferus ducts Moderate Uncertain testis Leydig cells Moderate Uncertain thyroid gland glandular cells Strong Uncertain tonsil germinal center cells Moderate Uncertain tonsil non-germinal center cells Moderate Uncertain tonsil squamous epithelial cells Moderate Uncertain urinary bladder urothelial cells Moderate Uncertain uterus, post-menopause cells in endometrial stroma Moderate Uncertain uterus, post-menopause glandular cells Moderate Uncertain uterus, pre-menopause cells in endometrial stroma Moderate Uncertain uterus, pre-menopause glandular cells Moderate Uncertain vagina squamous epithelial cells Moderate Uncertain vulva/anal skin epidermal cells Moderate Uncertain -
Gene Ontology
GO ID GO term PubMed Category GO:0045177 apical part of cell Component GO:0005737 cytoplasm 11260256 Component GO:0005829 cytosol Component GO:0030175 filopodium 11035016 Component GO:0000139 Golgi membrane Component GO:0005815 microtubule organizing center Component GO:0030496 midbody 15642749 Component GO:0072686 mitotic spindle 15642749 Component GO:0043005 neuron projection Component GO:0043025 neuronal cell body Component GO:0005886 plasma membrane 11260256 Component GO:0005886 plasma membrane Component GO:0030141 secretory granule Component GO:0051233 spindle midzone 15642749 Component GO:0005525 GTP binding Function GO:0030742 GTP-dependent protein binding Function GO:0003924 GTPase activity 11035016 Function GO:0031435 mitogen-activated protein kinase kinase kinase binding Function GO:0005515 protein binding 10051605 Function GO:0019901 protein kinase binding 19039103 Function GO:0019901 protein kinase binding Function GO:0031996 thioesterase binding 12612085 Function GO:0030036 actin cytoskeleton organization 11035016 Process GO:0051017 actin filament bundle assembly Process GO:0034332 adherens junction organization Process GO:0007411 axon guidance Process GO:0007596 blood coagulation Process GO:0060070 canonical Wnt receptor signaling pathway Process GO:0003161 cardiac conduction system development Process GO:0034613 cellular protein localization Process GO:0007173 epidermal growth factor receptor signaling pathway Process GO:0090136 epithelial cell-cell adhesion Process GO:0060684 epithelial-mesenchymal cell signaling Process GO:0051683 establishment of Golgi localization Process GO:0035088 establishment or maintenance of apical/basal cell polarity Process GO:0007163 establishment or maintenance of cell polarity 11260256 Process GO:0046847 filopodium assembly Process GO:0007030 Golgi organization Process GO:0006184 GTP catabolic process 11035016 Process GO:0031069 hair follicle morphogenesis Process GO:0060789 hair follicle placode formation Process GO:0060047 heart contraction Process GO:0031424 keratinization Process GO:0003334 keratinocyte development Process GO:0030225 macrophage differentiation 11260256 Process GO:0035264 multicellular organism growth Process GO:0042692 muscle cell differentiation Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Process GO:0010629 negative regulation of gene expression Process GO:0031333 negative regulation of protein complex assembly 11584266 Process GO:0048664 neuron fate determination Process GO:0007097 nuclear migration Process GO:0072384 organelle transport along microtubule Process GO:0071777 positive regulation of cell cycle cytokinesis 15642749 Process GO:0045740 positive regulation of DNA replication Process GO:0010628 positive regulation of gene expression Process GO:0071338 positive regulation of hair follicle cell proliferation Process GO:0046330 positive regulation of JNK cascade Process GO:0051149 positive regulation of muscle cell differentiation Process GO:0033138 positive regulation of peptidyl-serine phosphorylation Process GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Process GO:0031274 positive regulation of pseudopodium assembly 11035016 Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore 15642749 Process GO:0051489 regulation of filopodium assembly 14978216 Process GO:0007088 regulation of mitosis Process GO:0042176 regulation of protein catabolic process Process GO:0043497 regulation of protein heterodimerization activity Process GO:0045859 regulation of protein kinase activity Process GO:0031647 regulation of protein stability Process GO:0051056 regulation of small GTPase mediated signal transduction Process GO:0007264 small GTPase mediated signal transduction Process GO:0031295 T cell costimulation Process
- Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084