Gene: CDC42

  • Entrez Gene ID

  • Symbol

    • CDC42

  • Synonyms

    • CDC42Hs, G25K

  • Description

    • cell division cycle 42 (GTP binding protein, 25kDa)

  • Type of Gene

    • protein-coding

  • Chromosome

    • 1

  • Location

    • 1p36.1

  • RNA Seq 1

    Sample Expression RPKM
    adipose
    		32.11
    colon
    		21.67
    heart
    		22.69
    hypothalamus
    		35.68
    kidney
    		26.3
    liver
    		28.17
    lung
    		30.51
    ovary
    		17.03
    skeletalmuscle
    		12.38
    spleen
    		39.62
    testes
    		23.48

  • Protein

    Tissue Cell type Staining level Reliability
    adrenal gland glandular cells Moderate Uncertain
    appendix glandular cells Moderate Uncertain
    appendix lymphoid tissue Moderate Uncertain
    bone marrow hematopoietic cells Moderate Uncertain
    breast glandular cells Moderate Uncertain
    bronchus respiratory epithelial cells Moderate Uncertain
    cerebellum cells in granular layer Negative Uncertain
    cerebellum cells in molecular layer Weak Uncertain
    cerebellum Purkinje cells Moderate Uncertain
    cerebral cortex glial cells Weak Uncertain
    cerebral cortex neuronal cells Moderate Uncertain
    cervix, uterine glandular cells Moderate Uncertain
    cervix, uterine squamous epithelial cells Weak Uncertain
    colon glandular cells Moderate Uncertain
    duodenum glandular cells Moderate Uncertain
    epididymis glandular cells Moderate Uncertain
    esophagus squamous epithelial cells Moderate Uncertain
    fallopian tube glandular cells Moderate Uncertain
    gall bladder glandular cells Moderate Uncertain
    heart muscle myocytes Weak Uncertain
    hippocampus glial cells Moderate Uncertain
    hippocampus neuronal cells Moderate Uncertain
    kidney cells in glomeruli Moderate Uncertain
    kidney cells in tubules Moderate Uncertain
    lateral ventricle glial cells Weak Uncertain
    liver bile duct cells Moderate Uncertain
    liver hepatocytes Weak Uncertain
    lung macrophages Moderate Uncertain
    lung pneumocytes Moderate Uncertain
    lymph node germinal center cells Moderate Uncertain
    lymph node non-germinal center cells Moderate Uncertain
    nasopharynx respiratory epithelial cells Moderate Uncertain
    oral mucosa squamous epithelial cells Moderate Uncertain
    ovary ovarian stroma cells Weak Uncertain
    pancreas exocrine glandular cells Strong Uncertain
    pancreas islets of Langerhans Strong Uncertain
    parathyroid gland glandular cells Moderate Uncertain
    placenta decidual cells Moderate Uncertain
    placenta trophoblastic cells Strong Uncertain
    prostate glandular cells Moderate Uncertain
    rectum glandular cells Moderate Uncertain
    salivary gland glandular cells Moderate Uncertain
    seminal vesicle glandular cells Moderate Uncertain
    skeletal muscle myocytes Strong Uncertain
    skin epidermal cells Moderate Uncertain
    small intestine glandular cells Moderate Uncertain
    smooth muscle smooth muscle cells Weak Uncertain
    spleen cells in red pulp Moderate Uncertain
    spleen cells in white pulp Moderate Uncertain
    stomach, lower glandular cells Moderate Uncertain
    stomach, upper glandular cells Moderate Uncertain
    testis cells in seminiferus ducts Moderate Uncertain
    testis Leydig cells Moderate Uncertain
    thyroid gland glandular cells Strong Uncertain
    tonsil germinal center cells Moderate Uncertain
    tonsil non-germinal center cells Moderate Uncertain
    tonsil squamous epithelial cells Moderate Uncertain
    urinary bladder urothelial cells Moderate Uncertain
    uterus, post-menopause cells in endometrial stroma Moderate Uncertain
    uterus, post-menopause glandular cells Moderate Uncertain
    uterus, pre-menopause cells in endometrial stroma Moderate Uncertain
    uterus, pre-menopause glandular cells Moderate Uncertain
    vagina squamous epithelial cells Moderate Uncertain
    vulva/anal skin epidermal cells Moderate Uncertain

  • Gene Ontology

    GO ID GO term PubMed Category
    GO:0045177 apical part of cell Component
    GO:0005737 cytoplasm 11260256 Component
    GO:0005829 cytosol Component
    GO:0030175 filopodium 11035016 Component
    GO:0000139 Golgi membrane Component
    GO:0005815 microtubule organizing center Component
    GO:0030496 midbody 15642749 Component
    GO:0072686 mitotic spindle 15642749 Component
    GO:0043005 neuron projection Component
    GO:0043025 neuronal cell body Component
    GO:0005886 plasma membrane 11260256 Component
    GO:0005886 plasma membrane Component
    GO:0030141 secretory granule Component
    GO:0051233 spindle midzone 15642749 Component
    GO:0005525 GTP binding Function
    GO:0030742 GTP-dependent protein binding Function
    GO:0003924 GTPase activity 11035016 Function
    GO:0031435 mitogen-activated protein kinase kinase kinase binding Function
    GO:0005515 protein binding 10051605 Function
    GO:0019901 protein kinase binding 19039103 Function
    GO:0019901 protein kinase binding Function
    GO:0031996 thioesterase binding 12612085 Function
    GO:0030036 actin cytoskeleton organization 11035016 Process
    GO:0051017 actin filament bundle assembly Process
    GO:0034332 adherens junction organization Process
    GO:0007411 axon guidance Process
    GO:0007596 blood coagulation Process
    GO:0060070 canonical Wnt receptor signaling pathway Process
    GO:0003161 cardiac conduction system development Process
    GO:0034613 cellular protein localization Process
    GO:0007173 epidermal growth factor receptor signaling pathway Process
    GO:0090136 epithelial cell-cell adhesion Process
    GO:0060684 epithelial-mesenchymal cell signaling Process
    GO:0051683 establishment of Golgi localization Process
    GO:0035088 establishment or maintenance of apical/basal cell polarity Process
    GO:0007163 establishment or maintenance of cell polarity 11260256 Process
    GO:0046847 filopodium assembly Process
    GO:0007030 Golgi organization Process
    GO:0006184 GTP catabolic process 11035016 Process
    GO:0031069 hair follicle morphogenesis Process
    GO:0060789 hair follicle placode formation Process
    GO:0060047 heart contraction Process
    GO:0031424 keratinization Process
    GO:0003334 keratinocyte development Process
    GO:0030225 macrophage differentiation 11260256 Process
    GO:0035264 multicellular organism growth Process
    GO:0042692 muscle cell differentiation Process
    GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Process
    GO:0010629 negative regulation of gene expression Process
    GO:0031333 negative regulation of protein complex assembly 11584266 Process
    GO:0048664 neuron fate determination Process
    GO:0007097 nuclear migration Process
    GO:0072384 organelle transport along microtubule Process
    GO:0071777 positive regulation of cell cycle cytokinesis 15642749 Process
    GO:0045740 positive regulation of DNA replication Process
    GO:0010628 positive regulation of gene expression Process
    GO:0071338 positive regulation of hair follicle cell proliferation Process
    GO:0046330 positive regulation of JNK cascade Process
    GO:0051149 positive regulation of muscle cell differentiation Process
    GO:0033138 positive regulation of peptidyl-serine phosphorylation Process
    GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Process
    GO:0031274 positive regulation of pseudopodium assembly 11035016 Process
    GO:0051988 regulation of attachment of spindle microtubules to kinetochore 15642749 Process
    GO:0051489 regulation of filopodium assembly 14978216 Process
    GO:0007088 regulation of mitosis Process
    GO:0042176 regulation of protein catabolic process Process
    GO:0043497 regulation of protein heterodimerization activity Process
    GO:0045859 regulation of protein kinase activity Process
    GO:0031647 regulation of protein stability Process
    GO:0051056 regulation of small GTPase mediated signal transduction Process
    GO:0007264 small GTPase mediated signal transduction Process
    GO:0031295 T cell costimulation Process
  1. Krupp M et al. (2012) RNA-Seq Atlas - a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics, 28, 1184-1185. doi:10.1093/bioinformatics/bts084