Label (1)

• Embryonic stem cell (en)

Synonyms (1)

• hESc (exact synonym, en)

Type

• cell

Species

• Homo sapiens

URI (1)

• http://purl.org/obo/owl/FMA#FMA_82841

Superclass (2)

• Embryonic cell (Homo sapiens)
• epiblast cell

Subclass (0)

Relations (5)

• capable of

  • developmental process
  • stem cell division

• has part

  • biomolecule

• part of

  • embryo
  • Homo sapiens

• Gene
• Count
• Details

0
• 14-3-3 epsilon
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in YWHAE0/Y182)+++pan-JNK/SAPK1+++Inhibitor2/PPP1R2++++ABP-280++++++14-3-3 epsilon/…

• Aldh1a1
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    …ries include Sox2, En1 and Nanog (ratio of differentiated/undifferentiated hESC sample normalized spot intensity < 0.75, down-regulated), Gadph, Aldh1a1, Sdha, Tubb and Nestin (ratio .1.0,

• alpha-Catenin
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in alpha-Cateninmplekin/SYMPK++-Ras/NRAS++++Casein Kinase II alpha/CSNK2A1++++VAP33/VAPA+++…

• ARHA
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in ARHA+++++beta-Catenin/CTNNB1++++CDC42+++++AF6/MLLT4+++++PKC alpha++-Yes++++Rho/…

• ARTN
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in ARTN+SHC+++++GDNFR-alpha/Gfra1++-Jun+++IKK beta++++pan-JNK/SAPK1/MAPK10+++NBS1/…

• Bcl-x
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Bcl-xbin Receptor/PAR1/F2R+++SHPS-1/PTPNS1++++MCM5+++++Smad2/3++++Tyk2++++Jun+++…

  • + Reference

    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Bcl-xbin Receptor/PAR1/F2R+++SHPS-1/PTPNS1++++MCM5+++++Smad2/3++++Tyk2++++Jun+++…

• BDKRB2
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in BDKRB22++++Jun+++Bcl-x/BCL2L1++++Smad4/DPC4+++Stat5A++GPCRB2 Bradykinin Receptor/…

• C-Raf
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in RAF12++++++GRB2++++++MEK1/MAP2K1++++++PKA C++-PKA RI alpha++-PKC alpha++-C-Raf/…

• CASK
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in CASK1++++CDC42+++++AF6/MLLT4+++++PKC alpha++-Yes++++Rho/ARHA+++++ZO-1/TJP1+++++…

• catenin (cadherin-associated protein), beta 1, 88kDa
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Ctnnb12+++++++PP2A Catalytic alpha/PPP2CA+++++++EBP50/SLC9A3R1++++++beta-Catenin/…

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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Ctnnb12+++++++PP2A Catalytic alpha/PPP2CA+++++++EBP50/SLC9A3R1++++++beta-Catenin/…

• CCND3
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in CCND3ic alpha/PPP2CA+++++++EBP50/SLC9A3R1++++++beta-Catenin/Ctnnb1++++Cyclin D3/…

• CD9
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    Scale bars = 100 ?m.Figure 3Human embryonic stem cells stained with anti-CD9. …

• Cdc2
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Cdk1tor 3/SORT1+++-Endopeptidase 3.4.24.16/NLN++++IP3R-3++++SHC++++Gap Junction…

• CDC42
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in CDC42Catalytic alpha+++++++PKC iota++++++Sec8/SEC8L1+++++beta-Catenin/CTNNB1++++…

• Connexin 43
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    Many more genes highly up-regulated in the hESC sample in comparison with universal reference RNA… … [20]. Gja1) and Zic family member 3 heterotaxy 1 (Zic3) (Table 4) [20].

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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in GJA1PKA C++-PKA RI alpha++-PKC alpha++-C-Raf/RAF1++++ZO-1/TJP1+++++Connexin-43/…

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    For example, FGF2 protein was expressed highly in hESCs and expression of key members of the TGF?, Wnt, … …For example, FGF2 protein was expressed highly in Connexin 43/Stat and Gap junction pathways, namely Stat1, SMADs, GSK3?, ?-catenin and …

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    Proteins known to be expressed by hESCs and also identified by these assays, included Oct4, E-CAD, Connexin 43 and Hsp70.

• Crk
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Crk++GSK-3 beta++++Jun+++Casein Kinase II alpha/CSNK2A1++++Jak-StatStat1++++++…

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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Crk++GSK-3 beta++++Jun+++Casein Kinase II alpha/CSNK2A1++++Jak-StatStat1++++++…

• DNER
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    …ived signal estimates, indicating an enrichment of DNER in NPs relative to hESCDNER in NPs relative to hESCs (Figure 1C).

• DPC4
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Smad41/F2R+++SHPS-1/PTPNS1++++MCM5+++++Smad2/3++++Tyk2++++Jun+++Bcl-x/BCL2L1++++…

• Dusp4
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in Dusp4+C-Raf++++p38 alpha/SAPK2a++-G3BP+++++TFII-I/GTF2IRD1++++MST1/STK4++++MKP2/…

• E-Cadherin
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    Scale bars = 100 ?m.Figure 3Human embryonic stem cells stained with anti-CD9 (A), anti-E-Cadherin 100 ?m.Figure 3Human embryonic stem cells stained with anti-CD9 (A), anti-…

• EBP50
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in EBP50+++Smad4/DPC4+++Endoglin+-WntCtBP2+++++++PP2A Catalytic alpha/PPP2CA+++++++…

• EH domain binding protein 1
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    …he AS exon in the EHBP1 (EH domain binding protein 1) gene was included in hESCs but skipped in hCNS-SCns, anEHBP1re present in the derived NPs (Figure 7B). …

• eIF-4E
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    …ional and proteomic databases.Table 2Signal pathways that may be active in hESCsNameProteinmRNATGF ?Stat1++++++PAI-1/SERPINE1+++-… …ases.Table 2Signal pathways that may be active in eIF-4E++GRB2++++++MEK2/MAP2K2++++++PI3Kinase/PIK3R1+++++pan ERK/MAPK1+++++Crk++++…

• En1
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    …ries include Sox2, En1 and Nanog (ratio of differentiated/undifferentiated hESC sample normalized spot intensity < 0.75, down-regEn1h, Aldh1a1, Sdha, Tubb and Nestin (ratio .1.0, …

• EphA1
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    The 15 most enriched genes in hESCs included genes such as teratocarcinoma-derived g… …3 (p-value < 10?9). EphA1 (p-value < 10?9), and erbB3 (p-value < 10?9).